High-Protein Pizza Breakfast Casserole

Featured in: Warm Bake & Roast Recipes

This hearty morning dish combines a protein-rich Greek yogurt dough base with fluffy scrambled eggs, turkey pepperoni, and a blend of mozzarella and cheddar cheeses. The crust comes together quickly with just flour, baking powder, and yogurt, while the egg layer gets seasoned with oregano and garlic powder for authentic pizza flavors.

Bake everything together until the eggs are set and cheese turns golden and bubbly. Each serving delivers 22 grams of protein, making it an ideal choice for busy weekdays or feeding a hungry crowd. Customize with vegetables like bell peppers, mushrooms, or spinach for added nutrition.

Updated on Mon, 09 Feb 2026 10:18:05 GMT
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni slices on a wooden board. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni slices on a wooden board. | birchwhisk.com

Start your morning with a flavorful and satisfying twist on a classic favorite. This High-Protein Pizza Breakfast Casserole combines the comforting elements of a savory pizza with the nutritional punch of a hearty egg bake. Featuring a simple Greek yogurt dough base and topped with fluffy eggs, melty cheese, and turkey pepperoni, this dish is perfect for anyone looking to simplify their meal prep while hitting their protein goals.

Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni slices on a wooden board. Pin it
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni slices on a wooden board. | birchwhisk.com

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The foundation of this casserole is a soft and chewy crust made from just a few simple ingredients, including protein-rich Greek yogurt. By layering the toppings over a thin dough base, you get the structure of a pizza with the texture of a traditional casserole. It is an excellent way to feed a crowd or ensure you have a delicious breakfast ready to go for those busy weekday mornings.

Ingredients

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  • For the Greek Yogurt Dough:
  • 1 ½ cups (180 g) all-purpose flour
  • 2 teaspoons baking powder
  • ½ teaspoon salt
  • 1 cup (240 g) plain Greek yogurt (nonfat or 2%)
  • Toppings:
  • 8 large eggs
  • ½ cup (120 ml) low-fat milk
  • 1 cup (100 g) shredded part-skim mozzarella cheese
  • ½ cup (50 g) shredded reduced-fat cheddar cheese
  • ½ cup (60 g) turkey pepperoni slices
  • ½ teaspoon dried oregano
  • ½ teaspoon garlic powder
  • ¼ teaspoon black pepper
  • 2 tablespoons chopped fresh parsley (optional)

Instructions

Step 1: Prep
Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch (23x33 cm) sheet pan or casserole dish.
Step 2: Make the Dough
In a medium bowl, whisk together the flour, baking powder, and salt. Add the Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.
Step 3: Form the Base
Press the dough evenly into the prepared pan, forming a thin base.
Step 4: Whisk Eggs
In a large bowl, whisk together the eggs, milk, oregano, garlic powder, and black pepper until well combined.
Step 5: Assemble
Pour the egg mixture evenly over the dough base.
Step 6: Add Toppings
Sprinkle both cheeses over the eggs. Top with turkey pepperoni slices.
Step 7: Bake
Bake for 20–25 minutes, or until the eggs are set and the cheese is golden and bubbly.
Step 8: Cool and Serve
Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

To increase the nutritional value, try adding diced bell peppers, sliced mushrooms, or fresh spinach to the egg mixture for extra flavor and vitamins.

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Varianten und Anpassungen

You can easily swap the turkey pepperoni for cooked chicken sausage or vegetarian pepperoni slices depending on your dietary preferences.

Serviervorschläge

For an authentic pizza feel, serve your breakfast casserole with a side of warm marinara sauce for dipping.

Slice of High-Protein Pizza Breakfast Casserole on a white plate, revealing fluffy eggs and melty cheese for a hearty breakfast. Pin it
Slice of High-Protein Pizza Breakfast Casserole on a white plate, revealing fluffy eggs and melty cheese for a hearty breakfast. | birchwhisk.com

This High-Protein Pizza Breakfast Casserole is a fantastic way to enjoy the best of both worlds—nutritious breakfast and delicious pizza. Whether you're feeding the whole family or preparing meals for the week, this easy-to-make dish is sure to become a staple in your kitchen.

Frequently Asked Questions

Can I make this breakfast casserole ahead of time?

Yes, this dish reheats beautifully and stays fresh in the refrigerator for 3-4 days. Prepare the full casserole, let it cool completely, then store individual portions in airtight containers. Reheat in the microwave for 1-2 minutes or in a 350°F oven until warmed through.

What makes this breakfast high in protein?

The combination of Greek yogurt in the dough, eight eggs, and reduced-fat cheeses provides 22 grams of protein per serving. Greek yogurt contains nearly double the protein of regular yogurt, while eggs offer complete protein with all essential amino acids.

Can I substitute the turkey pepperoni?

Absolutely. Try chicken sausage, Canadian bacon, or vegetarian pepperoni slices. For a meatless version, increase the vegetables with diced bell peppers, mushrooms, spinach, or artichoke hearts. You can also use regular pepperoni if dietary restrictions aren't a concern.

Is the Greek yogurt dough difficult to work with?

Not at all. The dough comes together in minutes with just a spoon and brief kneading. It's more pliable than traditional pizza dough and presses easily into the pan. Use wet hands or a spatula if it sticks slightly to your fingers.

What size pan works best?

A 9x13-inch sheet pan or casserole dish creates the ideal thickness for both the crust and egg layers. If using a deeper dish, you may need to extend the baking time by 5-10 minutes to ensure the eggs cook through completely.

Can I freeze this breakfast casserole?

Yes, freeze baked and cooled portions for up to 2 months. Wrap individual slices tightly in plastic wrap and foil, then thaw overnight in the refrigerator before reheating. The texture remains excellent after freezing.

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High-Protein Pizza Breakfast Casserole

Savory breakfast bake with Greek yogurt crust, eggs, pepperoni and cheese. Perfect for meal prep.

Prep Time
20 Minutes
Cook Time
25 Minutes
Total Time
45 Minutes


Difficulty: Easy

Cuisine: American

Yield: 6 servings

Dietary: None specified

Ingredients

Greek Yogurt Dough

01 1.5 cups all-purpose flour
02 2 teaspoons baking powder
03 0.5 teaspoon salt
04 1 cup plain Greek yogurt, nonfat or 2%

Toppings

01 8 large eggs
02 0.5 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 0.5 cup shredded reduced-fat cheddar cheese
05 0.5 cup turkey pepperoni slices
06 0.5 teaspoon dried oregano
07 0.5 teaspoon garlic powder
08 0.25 teaspoon black pepper
09 2 tablespoons chopped fresh parsley, optional

Instructions

Step 01

Prepare the Pan and Preheat Oven: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish.

Step 02

Make the Dough Base: In a medium bowl, whisk together flour, baking powder, and salt. Add Greek yogurt and mix with a spoon until shaggy dough forms. Knead briefly until smooth.

Step 03

Press Dough Into Pan: Press dough evenly into prepared pan, forming a thin, uniform base layer.

Step 04

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until well combined.

Step 05

Assemble Casserole: Pour egg mixture evenly over dough base. Sprinkle both cheeses over eggs and top with turkey pepperoni slices.

Step 06

Bake Until Set: Bake for 20-25 minutes, or until eggs are set and cheese is golden and bubbly.

Step 07

Cool and Garnish: Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

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Tools You'll Need

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy
  • Check turkey pepperoni and cheese labels for additional allergen information

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 260
  • Total Fat: 10 g
  • Total Carbohydrate: 19 g
  • Protein: 22 g

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