High-Protein Pizza Breakfast Casserole

Featured in: Warm Bake & Roast Recipes

This hearty breakfast dish combines the comfort of pizza flavors with a nutritious start to your day. The base features a simple Greek yogurt dough that's both tender and protein-rich, topped with a savory egg mixture, melted cheese, and turkey pepperoni.

Perfect for meal prep, this casserole comes together in just 45 minutes and provides 20 grams of protein per serving. The self-rising flour creates a light, fluffy texture that pairs beautifully with the classic pizza toppings.

Bake until golden and bubbly, then slice into squares for an easy grab-and-go breakfast throughout the week. Customize with your favorite vegetables or add a spicy kick with red pepper flakes.

Updated on Sun, 08 Feb 2026 09:01:37 GMT
Freshly baked High-Protein Pizza Breakfast Casserole on a wooden board, featuring golden bubbly cheese, turkey pepperoni, and fresh basil garnish. Save
Freshly baked High-Protein Pizza Breakfast Casserole on a wooden board, featuring golden bubbly cheese, turkey pepperoni, and fresh basil garnish. | birchwhisk.com

Start your morning with a flavorful twist on a classic favorite with this High-Protein Pizza Breakfast Casserole. This hearty dish features a protein-rich Greek-yogurt dough base topped with fluffy eggs, savory turkey pepperoni, and melted cheese, making it the perfect nutritious start to your day. Whether you are looking for a satisfying weekend brunch or an easy-to-reheat option for busy mornings, this recipe brings all the satisfaction of pizza to the breakfast table.

Freshly baked High-Protein Pizza Breakfast Casserole on a wooden board, featuring golden bubbly cheese, turkey pepperoni, and fresh basil garnish. Pin it
Freshly baked High-Protein Pizza Breakfast Casserole on a wooden board, featuring golden bubbly cheese, turkey pepperoni, and fresh basil garnish. | birchwhisk.com

What's for Dinner Tonight? 🤔

Stop stressing. Get 10 fast recipes that actually work on busy nights.

Free. No spam. Just easy meals.

This sheet pan meal is not only delicious but also incredibly efficient for feeding a crowd. By using a 9x13-inch pan, you create even slices that are packed with protein from the Greek yogurt, eggs, and lean turkey pepperoni. The combination of mozzarella and cheddar cheeses provides that perfect golden, bubbly finish every pizza lover craves.

Ingredients

Tired of Takeout? 🥡

Get 10 meals you can make faster than delivery arrives. Seriously.

One email. No spam. Unsubscribe anytime.

  • Greek Yogurt Dough: 1 cup (245 g) plain Greek yogurt (2% or 0% fat), 1 cup (120 g) self-rising flour (plus extra for dusting), 1/2 tsp garlic powder, 1/2 tsp dried oregano, 1/4 tsp salt.
  • Toppings: 6 large eggs, 1/2 cup (120 ml) low-fat milk, 1 cup (110 g) shredded mozzarella cheese (part-skim), 1/2 cup (50 g) shredded cheddar cheese, 1/2 cup (40 g) turkey pepperoni slices, 1/2 cup (125 ml) pizza sauce (low-sugar preferred), 1/4 cup (25 g) diced bell pepper (optional), 1/4 cup (25 g) diced red onion (optional), 1 tbsp chopped fresh basil or parsley (optional, for garnish), salt and black pepper to taste.

Instructions

Step 1: Prep
Preheat oven to 400°F (200°C). Lightly grease or line a rimmed 9x13-inch sheet pan with parchment paper.
Step 2: Dough
In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms, then knead on a lightly floured surface for 2–3 minutes until smooth.
Step 3: Shape
Roll or press the dough into a rectangle to fit the prepared sheet pan, pressing it evenly to the edges.
Step 4: Base
Spread the pizza sauce evenly over the dough base.
Step 5: Eggs
In a large bowl, whisk together the eggs, milk, a pinch of salt, and black pepper until well combined.
Step 6: Cheese
Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.
Step 7: Assemble
Pour the egg mixture evenly over the cheese, then top with turkey pepperoni, the remaining cheese, bell pepper, and red onion if using.
Step 8: Bake
Bake for 22–25 minutes, or until the eggs are set and the cheese is golden and bubbly.
Step 9: Serve
Let cool for 5 minutes. Garnish with fresh herbs if desired, then slice and serve warm.

Zusatztipps für die Zubereitung

For the best results, ensure your sheet pan is properly greased or lined with parchment paper to prevent the dough from sticking. This casserole is very convenient as it can be prepped the night before and baked fresh in the morning.

Still Scrolling? You'll Love This 👇

Our best 20-minute dinners in one free pack — tried and tested by thousands.

Trusted by 10,000+ home cooks.

Varianten und Anpassungen

If you don't have self-rising flour, substitute it with 1 cup all-purpose flour, 1 1/2 tsp baking powder, and 1/4 tsp salt. For those who enjoy a bit of spice, add red pepper flakes or swap the turkey pepperoni for spicy turkey sausage.

Serviervorschläge

This high-protein dish pairs exceptionally well with a simple green salad for extra fiber or a side of fresh fruit for a touch of sweetness to balance the savory pizza flavors.

A single slice of High-Protein Pizza Breakfast Casserole is lifted, revealing fluffy eggs and melted mozzarella over a Greek yogurt crust. Pin it
A single slice of High-Protein Pizza Breakfast Casserole is lifted, revealing fluffy eggs and melted mozzarella over a Greek yogurt crust. | birchwhisk.com

With 270 calories and 20 grams of protein per serving, this High-Protein Pizza Breakfast Casserole is a delicious and functional way to start your day. It’s a versatile recipe that brings the joy of pizza to your morning routine while keeping you on track with your nutritional goals. Slice it up, share with family, and enjoy this savory breakfast delight.

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can assemble the entire casserole the night before and store it covered in the refrigerator. Bake fresh in the morning, or bake completely and reheat individual portions throughout the week.

What can I substitute for self-rising flour?

Mix 1 cup all-purpose flour with 1 ½ teaspoons baking powder and ¼ teaspoon salt. This combination will give you the same rising action and texture as self-rising flour.

How do I store leftovers?

Store cooled slices in an airtight container in the refrigerator for up to 4 days. Reheat in the microwave for 1-2 minutes or in a 350°F oven until warmed through.

Can I freeze this breakfast casserole?

Yes, wrap individual slices tightly in plastic wrap and foil, then freeze for up to 2 months. Thaw overnight in the refrigerator before reheating.

What other toppings work well?

Mushrooms, spinach, diced tomatoes, black olives, or cooked breakfast sausage all make excellent additions. Keep the total amount of toppings similar to avoid making the casserole too soggy.

Is Greek yogurt necessary for the dough?

Greek yogurt provides the structure and moisture needed for this two-ingredient dough technique. Plain regular yogurt can work, but the texture may be slightly different. The yogurt also contributes to the high protein content.

20-Minute Dinner Pack — Free Download 📥

10 recipes, 1 shopping list. Everything you need for a week of easy dinners.

Instant access. No signup hassle.

High-Protein Pizza Breakfast Casserole

Hearty breakfast casserole with Greek yogurt dough, eggs, pepperoni and cheese. Perfect for meal prep.

Prep Time
20 Minutes
Cook Time
25 Minutes
Total Time
45 Minutes


Difficulty: Easy

Cuisine: American

Yield: 6 servings

Dietary: None specified

Ingredients

Greek Yogurt Dough

01 1 cup plain Greek yogurt (2% or 0% fat)
02 1 cup self-rising flour, plus extra for dusting
03 1/2 teaspoon garlic powder
04 1/2 teaspoon dried oregano
05 1/4 teaspoon salt

Toppings

01 6 large eggs
02 1/2 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 1/2 cup shredded cheddar cheese
05 1/2 cup turkey pepperoni slices
06 1/2 cup low-sugar pizza sauce
07 1/4 cup diced bell pepper, optional
08 1/4 cup diced red onion, optional
09 1 tablespoon chopped fresh basil or parsley, optional for garnish
10 Salt and black pepper to taste

Instructions

Step 01

Prepare the Oven and Pan: Preheat oven to 400°F. Lightly grease a 9x13-inch rimmed sheet pan or line with parchment paper.

Step 02

Make the Dough Base: In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms. Knead briefly on a lightly floured surface until smooth, approximately 2 to 3 minutes.

Step 03

Shape the Dough: Roll or press dough into a rectangle to fit the prepared sheet pan. Transfer to pan and press evenly to the edges.

Step 04

Layer the Pizza Sauce: Spread pizza sauce evenly over the dough base.

Step 05

Prepare the Egg Mixture: In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.

Step 06

Add First Cheese Layer: Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.

Step 07

Pour Egg Custard: Pour the egg mixture evenly over the cheese layer.

Step 08

Top with Remaining Ingredients: Top casserole with turkey pepperoni, remaining cheese, bell pepper, and red onion if using.

Step 09

Bake the Casserole: Bake for 22 to 25 minutes, or until eggs are set and cheese is golden and bubbly.

Step 10

Cool and Serve: Remove from oven and let cool for 5 minutes. Garnish with fresh basil or parsley if desired. Slice and serve warm.

You Just Made Something Great 👏

Want more like this? Get my best easy recipes — free, straight to your inbox.

Join 10,000+ home cooks. No spam.

Tools You'll Need

  • Mixing bowls
  • Whisk
  • Rolling pin
  • 9x13-inch sheet pan
  • Parchment paper
  • Knife and cutting board

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy
  • Check pepperoni, cheese, and pizza sauce labels for additional allergens or additives

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 270
  • Total Fat: 12 g
  • Total Carbohydrate: 20 g
  • Protein: 20 g

Cooking Shouldn't Be Hard ❤️

Get a free recipe pack that makes weeknight dinners effortless. Real food, real fast.

Free forever. Unsubscribe anytime.