Spinach Artichoke Grilled Cheese

Featured in: Weekend Rustic Kitchen Favorites

Elevate your sandwich game with this spinach artichoke grilled cheese featuring a creamy blend of mozzarella, cream cheese, and Parmesan mixed with sautéed spinach and artichoke hearts. Butter the sourdough bread and cook until golden brown and melty for the ultimate comfort meal.

Preparation takes just 15 minutes, with another 10 minutes of cooking time. This vegetarian sandwich serves two and pairs beautifully with tomato soup. Customize with fresh basil or smoked paprika for extra depth.

Updated on Sun, 18 Jan 2026 10:07:00 GMT
Golden sourdough slices with melted mozzarella and a creamy spinach-artichoke filling hold beautifully in this gourmet Spinach Artichoke Grilled Cheese.  Save
Golden sourdough slices with melted mozzarella and a creamy spinach-artichoke filling hold beautifully in this gourmet Spinach Artichoke Grilled Cheese. | birchwhisk.com

My neighbor knocked on the door one rainy Tuesday holding a jar of marinated artichokes she didn't know what to do with. I had leftover spinach wilting in the fridge and a block of cream cheese that needed using. We stood in my kitchen, piecing together what became the best grilled cheese either of us had tasted in years. The rain kept falling, but we didn't notice.

I made this for my brother once after he complained that all vegetarian food was boring. He ate both sandwiches without saying a word, then asked if I had more bread. That was the highest compliment he'd given anything I'd cooked in a decade. Now he texts me every few months asking if I remember that spinach thing, and I send him the recipe again even though I know he won't make it himself.

Ingredients

  • Shredded mozzarella cheese: This melts beautifully and gives you those gorgeous cheese pulls without overpowering the other flavors.
  • Cream cheese, softened: The binder that holds everything together and adds a rich, tangy creaminess that makes the filling almost dip like.
  • Grated Parmesan cheese: A little goes a long way for that nutty, salty depth that rounds out the whole filling.
  • Unsalted butter, softened: Spread it on the outside of the bread for that golden, crispy crust that crackles when you bite into it.
  • Fresh spinach, chopped: Wilts down to almost nothing, so don't worry if it looks like too much at first.
  • Canned or jarred artichoke hearts, drained and chopped: Make sure to squeeze out as much liquid as you can, or your filling will be watery and your bread will get soggy.
  • Small garlic clove, minced: Just enough to wake everything up without making your breath regrettable.
  • Sourdough bread: The slight tang plays perfectly with the creamy filling, and it gets crispy without burning as easily as white bread does.
  • Salt, black pepper, and red pepper flakes: Season to your taste, but the pinch of heat from the red pepper flakes is what made my neighbor ask what my secret was.

Instructions

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Wilt the spinach:
Add the chopped spinach to a medium skillet over medium heat with just a splash of water. It only takes a minute or two for the leaves to collapse and turn bright green. Drain any excess water by pressing the spinach gently with a spoon, because extra moisture will make your sandwich soggy.
Mix the filling:
In a bowl, combine the wilted spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, minced garlic, salt, pepper, and red pepper flakes if you're using them. Stir until everything is evenly blended and the cream cheese has loosened up enough to coat the vegetables.
Assemble the sandwiches:
Spread the spinach artichoke mixture generously onto two slices of sourdough, then top each with another slice of bread. Press down gently so the filling doesn't slide out when you flip them later.
Butter the bread:
Spread softened butter on the outside of each sandwich, making sure to cover all the way to the edges. This is what gives you that even, golden crust without any pale spots.
Grill the sandwiches:
Heat a large nonstick skillet or griddle over medium heat and place the sandwiches in the pan. Cook for 3 to 4 minutes on each side, pressing gently with a spatula, until the bread is golden brown and the cheese inside has melted into a creamy, gooey filling.
Serve:
Remove the sandwiches from the heat, slice them in half, and serve immediately while the cheese is still warm and stretchy.
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A close-up of a crispy, buttery Spinach Artichoke Grilled Cheese sandwich oozing with warm, cheesy filling, served with a bowl of tomato soup.  Pin it
A close-up of a crispy, buttery Spinach Artichoke Grilled Cheese sandwich oozing with warm, cheesy filling, served with a bowl of tomato soup. | birchwhisk.com

I brought these sandwiches to a potluck once, cut into small squares, and they disappeared before the main dishes even came out. Someone asked if I'd catered it. I didn't have the heart to tell them it was just grilled cheese with vegetables. Sometimes the simplest things feel the most special when you share them with people who are hungry and happy to be together.

What to Serve With It

A bowl of tomato soup is the obvious choice, and it really does work beautifully, especially if you make it from scratch with a little cream stirred in at the end. But I've also served these with a simple green salad dressed in lemon and olive oil, or even alongside a cup of roasted red pepper soup when I want something a little different. If you're feeding kids, a handful of kettle chips on the side makes it feel like a treat without any extra effort.

How to Store Leftovers

If you somehow have leftovers, wrap them tightly in foil and keep them in the fridge for up to two days. Reheat them in a skillet over medium low heat instead of the microwave, which will make the bread soggy and the filling weep. You can also freeze the uncooked spinach artichoke mixture for up to a month and thaw it in the fridge overnight when you want a quick lunch. Just assemble and grill as usual, and no one will know it wasn't freshly made.

Ways to Make It Your Own

This recipe is forgiving and loves a little creativity. Swap the sourdough for a sturdy whole wheat or even a seeded multigrain if you want more texture. Add a handful of chopped fresh basil or a few sun dried tomatoes to the filling for extra brightness. If you like things spicy, a thin layer of hot pepper jelly on the inside of the bread before you add the filling will give you a sweet heat that's completely addictive.

  • Try using fontina or Gruyere instead of mozzarella for a richer, nuttier flavor.
  • A sprinkle of smoked paprika in the filling adds a subtle depth that makes people ask what's different.
  • If you're gluten free, use your favorite gluten free bread and check that your cheese and artichokes don't have any hidden wheat.
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A golden-brown Spinach Artichoke Grilled Cheese, sliced to reveal the vibrant green spinach and tender artichoke hearts nestled in melted cheese. Pin it
A golden-brown Spinach Artichoke Grilled Cheese, sliced to reveal the vibrant green spinach and tender artichoke hearts nestled in melted cheese. | birchwhisk.com

This sandwich turned a random Tuesday into something worth remembering, and it's done the same on a dozen ordinary days since. I hope it does that for you too.

Frequently Asked Questions

Can I prepare the spinach artichoke filling ahead of time?

Yes, you can make the filling up to 24 hours in advance. Store it in an airtight container in the refrigerator and assemble the sandwiches when ready to cook.

What bread alternatives work best for this sandwich?

While sourdough provides ideal flavor and texture, you can substitute whole wheat, multigrain, or thick-cut white bread. Avoid overly thin bread that may tear when pressing during cooking.

How do I prevent the cheese from leaking out while cooking?

Spread the filling evenly across both bread slices and avoid overfilling. Press gently with your spatula while cooking rather than applying heavy pressure, which forces the filling out.

Can I make this with non-dairy cheese substitutes?

Yes, use dairy-free mozzarella and cream cheese alternatives. Choose brands designed for melting to achieve the best creamy texture in your filling.

What's the best way to achieve perfectly golden bread without burning it?

Cook over medium heat and monitor closely. Butter the exterior generously for even browning, and aim for 3-4 minutes per side. Lower heat if the bread darkens too quickly.

Are there flavor variations I can try?

Add fresh basil, red pepper flakes, sun-dried tomatoes, or caramelized onions to the filling. Smoked paprika enhances the savory profile, and a pinch of nutmeg complements the spinach beautifully.

Spinach Artichoke Grilled Cheese

Gourmet grilled cheese with creamy spinach and artichoke filling on golden sourdough. Ready in 25 minutes.

Prep Time
15 Minutes
Cook Time
10 Minutes
Total Time
25 Minutes


Difficulty: Easy

Cuisine: American

Yield: 2 servings

Dietary: Vegetarian

Ingredients

Dairy

01 1 cup shredded mozzarella cheese
02 1/2 cup cream cheese, softened
03 1/4 cup grated Parmesan cheese
04 2 tablespoons unsalted butter, softened

Vegetables

01 1 cup fresh spinach, chopped
02 1/2 cup canned or jarred artichoke hearts, drained and chopped
03 1 small garlic clove, minced

Bread

01 4 slices sourdough bread

Seasonings

01 1/4 teaspoon salt
02 1/8 teaspoon freshly ground black pepper
03 Pinch of red pepper flakes, optional

Instructions

Step 01

Prepare spinach: In a medium skillet over medium heat, add spinach and a splash of water. Sauté for 1 to 2 minutes until wilted. Drain excess moisture thoroughly.

Step 02

Combine filling ingredients: In a bowl, combine sautéed spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, garlic, salt, pepper, and red pepper flakes. Mix until well blended.

Step 03

Assemble sandwiches: Spread the spinach-artichoke mixture evenly onto two slices of sourdough. Top with the remaining bread slices to form sandwiches.

Step 04

Butter bread exterior: Butter the outsides of all bread slices generously.

Step 05

Cook sandwiches: Heat a large nonstick skillet or griddle over medium heat. Place sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 06

Serve: Remove from heat, slice in half diagonally, and serve immediately.

Tools You'll Need

  • Medium skillet
  • Mixing bowl
  • Spatula
  • Nonstick skillet or griddle
  • Knife

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains milk (cheese, butter)
  • Contains wheat (sourdough bread)
  • May contain traces of soy or nuts depending on bread and cheese brands

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 430
  • Total Fat: 24 g
  • Total Carbohydrate: 39 g
  • Protein: 16 g